Pseudomonas cepacia susceptibility to sulbactam

Area of Science:

• Microbiology
• Antimicrobial Resistance
• Pharmacology

Background:

• Pseudomonas cepacia is an opportunistic pathogen.
• Antimicrobial susceptibility testing is crucial for effective treatment.

Purpose of the Study:

• To determine the susceptibility of Pseudomonas cepacia isolates to sulbactam.
• To evaluate the reliability of a sulbactam-ampicillin disk test for predicting susceptibility.

Main Methods:

• Agar dilution method was used to determine MICs of sulbactam.
• Susceptibility testing was performed on 32 Pseudomonas cepacia isolates.
• A commercial sulbactam-ampicillin disk was used for comparison.

Main Results:

• 25 out of 32 Pseudomonas cepacia isolates exhibited a sulbactam MIC of 2.5 µg/ml.
• Only one isolate showed a sulbactam MIC greater than 80 µg/ml.
• The sulbactam-ampicillin disk test accurately predicted susceptibility.

Conclusions:

• Pseudomonas cepacia isolates are generally susceptible to sulbactam.
• The sulbactam-ampicillin disk test is a reliable method for predicting sulbactam susceptibility in these isolates.