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Updated: Mar 19, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Mechanistic Studies of Octahydrophenazine Formation from a 2-Hydroxycyclohexanone/Ammonium Acetate Model System in
T C Huang1, H Y Fu1,2, C T Ho1,2
1a Department of Food Science and Technology , National Pingtung Polytechnic Institute , Pingtung 912 , Taiwan.
Abstract:
Synopsis Model systems composed of 2-hydroxycyclohexanone and ammonium acetate in a mole ratio of 1 to 3 were set up to study the formation of octahydrophenazine (OHP). Octahydrophenazine and an intermediate were isolated and characterized by GC/MS (El and Cl). This intermediate was the condensation product between a molecule of 2-hydroxycyclohexanone and 2-amino-cyclohexanone via the SchifT base formation mechanism. A larger amount of the intermediate than of OHP was found in the solvent system containing less than 20% ethanol, the relative proportion of the intermediate decreasing as the percentage of ethanol was increased. The formation mechanism for OHP is proposed.
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