Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

124.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
124.5K
Spermatogenesis01:22

Spermatogenesis

10.6K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
10.6K
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

4.6K
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
4.6K
The Y Chromosome Determines Maleness02:19

The Y Chromosome Determines Maleness

8.7K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
8.7K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.9K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.9K
Master Transcription Regulators02:23

Master Transcription Regulators

8.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of dual specificity phosphatase 1 in influencing inflammatory pathways in macrophages modulated by <i>Borrelia burgdorferi</i> lipoproteins.

Frontiers in immunology·2026
Same author

Lymphotoxin-beta receptor controls the development of chronic pain.

Cell reports·2026
Same author

Masticatory myalgia to headache-like secondary hypersensitivity induces gene plasticity at dura mater.

The journal of headache and pain·2026
Same author

Spinal glial cell derived extra-pituitary prolactin contributes to postoperative pain in females.

Frontiers in aging neuroscience·2026
Same author

Rete ridges form via evolutionarily distinct mechanisms in mammalian skin.

Nature·2026
Same author

Recovery of high-quality sperm after cryopreservation in the common marmoset (Callithrix jacchus)†.

Biology of reproduction·2026
Same journal

Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.

Results and problems in cell differentiation·2026
Same journal

Mechanobiology of Myelin Generation/Regeneration in Health and Disease.

Results and problems in cell differentiation·2026
Same journal

Epigenetic Regulation of RUNX2 in Bone Mechanobiology.

Results and problems in cell differentiation·2026
Same journal

Integrating Mechanical Loading, Mechanotransduction, and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix, and Sex.

Results and problems in cell differentiation·2026
Same journal

Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.

Results and problems in cell differentiation·2026
Same journal

Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.

Results and problems in cell differentiation·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

16.0K

Mechanisms Regulating Spermatogonial Differentiation.

Jennifer M Mecklenburg1, Brian P Hermann2

  • 1Department of Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.

Results and Problems in Cell Differentiation
|June 15, 2016
PubMed
Summary
This summary is machine-generated.

This review explores mammalian spermatogenesis, focusing on how spermatogonial stem cells (SSCs) decide to differentiate. It details the early events in spermatogonium development and the journey to sperm formation.

Keywords:
Cell fateDifferentiating spermatogoniaSpermatogonial stem cells

More Related Videos

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
08:21

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye

Published on: January 14, 2021

6.6K
Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment
10:22

Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment

Published on: September 17, 2019

12.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

16.0K
Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
08:21

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye

Published on: January 14, 2021

6.6K
Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment
10:22

Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment

Published on: September 17, 2019

12.4K

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Spermatogenesis is the process of male gamete formation in mammals.
  • Adult stem cells, spermatogonial stem cells (SSCs), initiate this lineage.
  • SSCs must make critical fate decisions to differentiate into progenitor cells.

Purpose of the Study:

  • To review current literature on spermatogonial differentiation.
  • To emphasize mechanisms controlling SSC fate decisions.
  • To highlight early differentiation events in spermatogonia.

Main Methods:

  • Literature review of spermatogenesis and stem cell differentiation.
  • Analysis of molecular and cellular mechanisms.
  • Focus on stem cell fate determination and early development.

Main Results:

  • Spermatogonial differentiation involves a series of precisely regulated steps.
  • Stem cell fate decisions are crucial for initiating spermatogenesis.
  • Early differentiation events prepare cells for meiosis and spermiogenesis.

Conclusions:

  • Understanding SSC fate decisions is key to comprehending spermatogenesis.
  • Early spermatogonial development is a complex, regulated process.
  • This review consolidates knowledge on critical early stages of male germ cell development.