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Updated: Mar 19, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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Published on: June 2, 2021

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Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy

Pierre Bruhns1, Jean-Luc Teillaud2

  • 1Unit of Antibodies in Therapy and Pathology, Department of Immunology, Institut Pasteur, Paris 75015, France; INSERM, U1222, Paris 75015, France.

Cancer Cell
|June 15, 2016
PubMed

In this issue of Cancer Cell, Dahan and colleagues demonstrate that modified Fc regions of agonistic anti-human CD40 mAbs can drastically increase their efficiency in a mouse pre-clinical model expressing human CD40 and IgG receptors. This study also highlights the fine balance between increased treatment efficacy and secondary side effects.

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