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Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
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General and Specific Mouse Models for Asthma Research.
Fernando Marqués-García1,2, Elena Marcos-Vadillo3,4
1Department of Clinical Biochemistry, University Hospital of Salamanca, Paseo de San Vicente 58, Salamanca, 37007, Spain. f.marg@hotmail.es.
Methods in Molecular Biology (Clifton, N.J.)
|June 15, 2016
Summary
Mouse models are crucial for understanding complex human asthma. This chapter details protocols for developing and utilizing these animal models to study asthma phenotypes.
Area of Science:
- Immunology
- Pulmonology
- Animal Modeling
Background:
- Human asthma is a complex respiratory disease requiring sophisticated study methods.
- Animal models are essential for investigating disease mechanisms and testing interventions.
- Mice are a widely used and valuable model organism in asthma research.
Purpose of the Study:
- To outline the necessity of diverse animal models for asthma research.
- To highlight the utility of mouse models in studying asthma.
- To provide protocols for designing asthma animal models focused on phenotypes.
Main Methods:
- Review and description of established protocols for creating asthma models in mice.
- Focus on methodologies enabling the study of specific asthma phenotypes.
- Adaptation of existing techniques for comprehensive asthma modeling.
Main Results:
- Detailed protocols for generating various mouse models of asthma are presented.
- The described models facilitate the investigation of distinct asthma characteristics.
- Methodologies are provided for analyzing asthma phenotypes in these models.
Conclusions:
- Mouse models are indispensable tools for dissecting the complexity of human asthma.
- The provided protocols enable the development of tailored models for specific research questions.
- This work supports the advancement of asthma research through standardized animal modeling techniques.
