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Related Experiment Video

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Directional sensing and streaming in Dictyostelium aggregation.

Sofia Almeida1, Rui Dilão2

  • 1Inria, BIOCORE, Centre de Recherche Inria Sophia Antipolis - Méditerranée, 06902 Sophia Antipolis, France.

Physical Review. E
|June 15, 2016
PubMed
Summary

This study integrates models of Dictyostelium discoideum (Dictyostelium) cyclic adenosine monophosphate (cAMP) production and directional sensing to explain aggregation patterns. The combined model accurately predicts target waves, spiral waves, and streaming behaviors observed in Dictyostelium.

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Area of Science:

  • Cellular biology
  • Biophysics
  • Mathematical modeling

Background:

  • Dictyostelium discoideum (Dictyostelium) aggregation involves complex signaling dynamics.
  • Previous models have addressed cyclic adenosine monophosphate (cAMP) production or directional sensing separately.

Purpose of the Study:

  • To develop a unified model of Dictyostelium aggregation.
  • To elucidate the mechanisms driving transient pattern formation during aggregation.

Main Methods:

  • Merging the Kessler-Levine discrete model for cAMP dynamics with the Dilão-Hauser directional sensing mechanism.
  • Simulating the emergent behaviors of Dictyostelium aggregation.

Main Results:

  • The compound model successfully reproduces known transient patterns: target waves, spiral waves, and streaming.
  • Streaming patterns are shown to be dependent on amoeba speed, cAMP production relaxation time, cAMP degradation rate, and directional sensing.
  • The emergence of multiple signaling centers during aggregation is demonstrated.

Conclusions:

  • The integrated model provides a comprehensive framework for understanding Dictyostelium aggregation.
  • The study highlights the interplay between cAMP signaling and directional sensing in pattern formation.
  • The findings offer insights into the self-organization processes in cellular slime molds.