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Updated: Mar 19, 2026

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β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ

Congcong Wang1,2, Xianglu Zeng1,3,4, Zhaocai Zhou1

  • 1State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

Scientific Reports
|June 16, 2016
PubMed
Summary

Beta-arrestin-1 knockout mice exhibit improved cold tolerance. This protein directly interacts with PPARs, influencing their activity and brown adipose tissue function, revealing a novel regulatory pathway for energy homeostasis.

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