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Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

Mohammad A Khanfar1, Anna Affini2, Kiril Lutsenko2

  • 1Stark Lab, Institut fuer Pharmazeutische and Medizinische Chemie, Heinrich-Heine-Universitaet DuesseldorfDuesseldorf, Germany; Faculty of Pharmacy, The University of JordanAmman, Jordan.

Frontiers in Neuroscience
|June 16, 2016
PubMed
Summary

Novel multifunctional histamine H3 receptor antagonists are gaining interest, especially after pitolisant (Wakix®) market approval. These compounds offer improved effects and reduced side-effects through polypharmacology, targeting various receptors and signaling pathways.

Keywords:
GPCRNOenzymeshistaminemultiple targetingtransporter

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