Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

8.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.4K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.8K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating emergency rescue readiness on Indian national highways: A case study of Jaipur-Jodhpur Highways (India) using a geospatial approach.

Journal of family medicine and primary care·2024
Same author

Analysis of the Thickness of Ligamentum Flavum and Its Relationship With Degenerative Disc Changes at L3-4, L4-5, and L5-S1 Levels in Patients Undergoing Magnetic Resonance Imaging (MRI) of the Lumbosacral Spine.

Cureus·2024
Same author

Constrictive pericarditis following epicardial pacemaker implant: a diagnostic dilemma.

Cardiology in the young·2024
Same author

Association Between Vitamin D Deficiency and Sepsis in Term Neonates: A Case-Control Study.

Cureus·2024
Same author

Collaboration Across Disciplines to Integrate Clinical Expertise into Medical Software Development: The Approach of the Dedalus Medical Office.

Studies in health technology and informatics·2024
Same author

Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing.

MicroRNA (Shariqah, United Arab Emirates)·2024
Same journal

Progressive Epiglottic Deformity and Acute Supraglottic Edema: A Fatal Combination in Behçet's Disease.

Ear, nose, & throat journal·2026
Same journal

Should a Tissue Cuff Be Preserved During Auricular Lobule Keloid Excision to Reduce Recurrence?

Ear, nose, & throat journal·2026
Same journal

Middle Turbinate Fibroepithelial Polyp as a Developmental Anomaly of the Nasal Cavity: A Case Report and Review of the Literature.

Ear, nose, & throat journal·2026
Same journal

Eggshell-like Intraosseous Cyst of the Ethmoid Perpendicular Plate: Imaging Clues and Endoscopic Management.

Ear, nose, & throat journal·2026
Same journal

Thyroiditis With IgG4 Plasma Cells.

Ear, nose, & throat journal·2026
Same journal

GLP-1 Receptor Agonists and THRIVE-Assisted Airway Surgery: The Need for Procedure-specific Evidence.

Ear, nose, & throat journal·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

1.1K

Hyperthyroidism in patients with thyroid cancer.

Sunil Dutt Sharma1, Gaurav Kumar, Karen Guner

  • 1Department of Otorhinolaryngology, Queens Hospital, Rom Valley Way, Romford, Essex RM7 0AG, UK. sunilsharma@doctors.org.uk.

Ear, Nose, & Throat Journal
|June 16, 2016
PubMed
Summary
This summary is machine-generated.

Hyperthyroidism in thyroid cancer patients (12%) warrants careful evaluation. Patients with autonomously functioning toxic nodules (AFTN) showed poorer outcomes than those with Graves disease, suggesting more aggressive cancer.

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.4K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.7K

Related Experiment Videos

Last Updated: Mar 19, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

1.1K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.4K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.7K

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Hyperthyroidism and thyroid cancer can coexist, necessitating understanding of their clinical interplay.
  • The incidence and outcomes of thyroid cancer in hyperthyroid patients require further investigation.

Purpose of the Study:

  • To analyze the clinical characteristics and outcomes of patients with both hyperthyroidism and thyroid cancer.
  • To identify specific patient groups requiring heightened diagnostic scrutiny.

Main Methods:

  • Retrospective case series of 66 thyroid cancer patients diagnosed between 2006-2013.
  • Biochemical and histopathological data reviewed for 8 patients with concurrent hyperthyroidism.
  • Comparison of clinical features and prognosis between subgroups: autonomously functioning toxic nodule (AFTN) and Graves disease.

Main Results:

  • Eight patients (12%) presented with both hyperthyroidism and thyroid cancer, all diagnosed with papillary thyroid carcinoma.
  • Tumor size was significantly larger in the AFTN group compared to the Graves disease group (42.3 mm vs. 3.8 mm).
  • Patients with AFTN exhibited poorer prognosis, including extracapsular invasion, lymph node metastasis, and disease-related death, unlike those with Graves disease.

Conclusions:

  • Hyperthyroidism is relatively common in thyroid cancer patients (12%).
  • Contrary to prior literature, AFTN associated with thyroid cancer may indicate more aggressive disease and worse outcomes than Graves disease.
  • Suspicious thyroid nodules in hyperthyroid patients warrant thorough evaluation.