Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Gallbladder01:17

Gallbladder

2.8K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Price of a Whipple: Predicting Hospital Charges Using Preoperative Patient Characteristics.

World journal of surgery·2026
Same author

Navigating cholecystitis in an ectopic pelvic liver: a surgical challenge after omphalocele repair.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2025
Same author

Bile Duct Injury: A Novel Risk Stratification System for the Timing of Repair.

The American surgeon·2025
Same author

Advances in minimally invasive liver surgery: comparing robotic and laparoscopic approaches.

Hepatobiliary surgery and nutrition·2025
Same author

Yttrium-90 Radioembolization for Intrahepatic Cholangiocarcinoma: Non-University Tertiary Care Center Experience.

Surgical innovation·2025
Same author

Same day discharge after hepatectomy: Can it be done safely?

Journal of hepato-biliary-pancreatic sciences·2024

Related Experiment Video

Updated: Mar 19, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

122

T2 Gallbladder Cancer-Aggressive Therapy Is Warranted.

Mohd Raashid Sheikh1, Houssam Osman, Susannah Cheek

  • 1Methodist Dallas Medical Center, Dallas, Texas, UJSA.

The American Surgeon
|June 17, 2016
PubMed
Summary

Radical cholecystectomy is crucial for T2 gall bladder cancer (GBC). Up to 60% of T2 GBC cases show lymph node positivity or are upstaged after further surgery, underscoring the need for this aggressive approach.

More Related Videos

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

908
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

28.0K

Related Experiment Videos

Last Updated: Mar 19, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

122
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

908
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

28.0K

Area of Science:

  • Surgical Oncology
  • Gastrointestinal Oncology

Background:

  • Gall bladder cancer (GBC) historically has a poor prognosis, particularly with lymph node involvement.
  • The optimal surgical management for T2 GBC remains a subject of investigation.

Purpose of the Study:

  • To evaluate the impact and necessity of radical cholecystectomy in patients diagnosed with T2 gall bladder cancer.
  • To assess the rate of lymph node positivity and tumor upstaging in T2 GBC following radical resection.

Main Methods:

  • Retrospective analysis of patients who underwent surgery for GBC between 2005 and 2014.
  • Inclusion of clinical, operative, and histopathological data, focusing on T2 tumors and those incidentally diagnosed.

Main Results:

  • 60% of T2 GBC patients exhibited lymph node positivity.
  • Radical cholecystectomy led to upstaging in 60% of T2 cases, with some progressing to T3 or N1.
  • Imaging diagnosis of GBC often revealed unresectable disease or advanced stages (T3+/N1).

Conclusions:

  • Radical resection is recommended for incidentally diagnosed T2 GBC.
  • Radical surgery plays a vital role in accurate staging of gall bladder cancer.