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Influence of hypoxia on the age dependent stimulus-effect-relation of K+-induced dopamine release from rat brain
K Mühl1, H D Fischer, E Rudolph
1Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, DDR.
Abstract:
There is a well defined correlation between stimulus intensity (potassium concentration) and the so-called fractional efflux rate of radio-labelled neurotransmitter from loaded brain structures. K+-induced dopamine release shows an age-dependent parallel shift of the stimulus-effect-relation which obviously reflects quantitative developmental changes during maturation (increasing release) and involution (restricted release) of neuronal structures and functions without modification of involved mechanisms in a qualitative manner. On the other side, mild hypoxia results in quite different, even opposite changes of the stimulus-effect-relation exhibiting the most diverse vulnerability and reactivity of neuronal stimulus-release-coupling at different age.