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Lipid Based Nanosystems for Curcumin: Past, Present and Future.

Aditya P Nayak¹, Tom Mills, Ian Norton

¹School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. a.nayak.1@bham.ac.uk.

Current Pharmaceutical Design

|June 17, 2016

Summary

Lipid-based nanotechnology enhances curcumin's stability and effectiveness for health and disease prevention. This approach overcomes limitations, bridging research to clinical applications for "Indian Gold".

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Area of Science:

Nanotechnology and Pharmaceutical Sciences
Nutraceuticals and Food Science
Ayurvedic Medicine

Background:

Curcumin, a bioactive compound from Ayurvedic medicine, possesses broad therapeutic potential but suffers from poor stability.
Instability issues related to pH, temperature, oxygen, and light limit curcumin's clinical efficacy and bioavailability.
Existing research highlights the need for advanced delivery systems to harness curcumin's full health benefits.

Purpose of the Study:

To review the use of lipid-based nanodelivery systems for enhancing curcumin's stability and bioactivity.
To explore the potential of these systems in pharmaceutical and food applications for health promotion and disease prevention.
To discuss future prospects for lipid-based curcumin delivery systems.

Main Methods:

Review of existing literature on lipid-based delivery systems for curcumin, including liposomes, solid lipid nanoparticles, and emulsions.
Analysis of studies focusing on improved stability, bioavailability, and pharmacokinetic profiles of nano-encapsulated curcumin.
Synthesis of data on the application of these systems in both pharmaceutical and food contexts.

Main Results:

Lipid-based nanodelivery systems significantly enhance curcumin's stability and overcome pharmacokinetic limitations.
These systems demonstrate potential for improved therapeutic outcomes in various health conditions.
Successful application of nano-curcumin in both medicinal and food products is supported by current research.

Conclusions:

Lipid-based nanocarriers are highly effective in stabilizing curcumin and improving its bioavailability.
Nanotechnology offers a viable strategy to translate curcumin's benchtop potential into clinical and dietary benefits.
Further research into lipid-based systems promises expanded applications for curcumin in health and disease management.