Related Experiment Videos
Antihypoxic effects of AWD 23-15 in mice and rats
E Morgenstern1, A Rostock, C Siegemund
1Institute of Pharmacological Research, Berlin, GDR.
Biomedica Biochimica Acta
|January 1, 1989
Abstract:
AWD 23-15 (6-Methyl-1,2,3,4-tetrahydro-pyrimidin-2,4 dion) which is known to improve learning and memory processes in laboratory animals, was investigated in several hypoxia models. The following results were obtained: 1. Increase of survival rate, 2. change in hypoxia-induced decrease of cerebral post-mortem adenylic energy charge and in concentrations of metabolic products in the brain and 3. antagonism of the hypoxia-induced decrease of dopamine release. However in the general behavioral test the drug was ineffective. These results support the idea that AWD 23-15 is a potential nootropic drug.