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Renal biofiltration.
N K Man1, C Ciancioni, B Perrone
1Necker Hospital, Nephrology Department, Inserm U 90, Paris, France.
ASAIO Transactions
|January 1, 1989
Summary
Biofiltration, a hemodiafiltration method, offers a simple, safe alternative to bicarbonate dialysis. This technique effectively manages plasma bicarbonate levels and is a promising approach for future short-time, high-quality dialysis treatments.
Area of Science:
- Nephrology
- Renal Replacement Therapy
Background:
- Bicarbonate dialysis presents challenges due to complex hardware and frequent troubleshooting.
- Biofiltration offers a simplified approach to hemodiafiltration using a base-free dialysate and bicarbonate infusion.
Purpose of the Study:
- To evaluate the efficacy and safety of biofiltration as an alternative to bicarbonate dialysis.
- To assess the suitability of biofiltration for short-time, high-quality dialysis strategies.
Main Methods:
- A long-term follow-up study (6-24 months) involving 76 patients across 17 European dialysis centers.
- Patients underwent a dialysis strategy of 3 hours, three times a week.
- Monitoring of sodium dialysate concentration and bicarbonate infusion flow rate was crucial.
Main Results:
- Biofiltration demonstrated a simple and safe alternative to bicarbonate dialysis.
- Adequate sodium mass balance can be achieved through careful monitoring.
- Plasma bicarbonate levels are easily controlled by adjusting the infusion flow rate.
Conclusions:
- Biofiltration is a viable and safe alternative to bicarbonate dialysis.
- The technique supports the trend towards shorter, higher-quality dialysis sessions.
- Consideration of the additional costs for high-flux dialyzers and infusion fluid is necessary.