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Published on: April 16, 2019
Aiolos and Lymphocyte Mimicry in Lung Cancer
1Department of Internal Medicine, Pulmonary and Critical Care; University of Texas, Southwestern Medical Center; Dallas, TX USA.
Abstract:
Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.
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