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Impact of acetylation on tumor metabolism

Di Zhao1, Fu-Long Li1, Zhou-Li Cheng1

  • 1Key Laboratory of Molecular Medicine; Ministry of Education, and Department of Biochemistry and Molecular Biology; Fudan University Shanghai Medical College; Shanghai, People's Republic of China; Molecular and Cell Biology Lab; Institutes of Biomedical Sciences; Fudan University; Shanghai, People's Republic of China.

Molecular & Cellular Oncology
|June 17, 2016
PubMed

Insights

Protein acetylation, regulated by HATs and HDACs/SIRTs, impacts nuclear and metabolic proteins. This review highlights acetylation

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Protein acetylation is a dynamic post-translational modification.
  • Acetylation affects nuclear, cytoplasmic, and mitochondrial proteins, including metabolic enzymes.
  • Tumor cells reprogram metabolism to support proliferation.

Purpose of the Study:

  • To review substrates modified by acetylation.
  • To focus on acetylation's role in tumor metabolism.
  • To highlight acetylation of oncogenes, tumor suppressors, and metabolic enzymes.

Main Methods:

  • Literature review and synthesis.
  • Analysis of existing research on protein acetylation.
  • Focus on studies implicating acetylation in cancer metabolism.

Main Results:

  • Acetylation modifies numerous proteins, including key players in cancer.
  • Specific acetylation targets include oncogenes, tumor suppressor genes, and metabolic enzymes.
  • Dysregulated acetylation contributes to altered tumor metabolism.

Conclusions:

  • Acetylation is a critical regulator of tumor metabolism.
  • Targeting acetylation pathways may offer novel cancer therapies.
  • Further research is needed to fully elucidate acetylation's role in oncogenesis.
Keywords:
acetylationmetabolic enzymeoncogenetumor metabolismtumor suppressor

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