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Reactive oxygen species: The good, the bad, and the enigma

Müge Ogrunc1

  • 1IFOM Foundation - FIRC Institute of Molecular Oncology Foundation ; Milan, Italy.

Molecular & Cellular Oncology
|June 17, 2016
PubMed

Insights

Ras proteins stimulate reactive oxygen species (ROS) production, promoting cell proliferation and DNA damage. The RAS-RAC1-NOX4 pathway is key to this process, impacting cell growth and aging.

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Genetics

Background:

  • Ras proteins are key regulators of cell signaling.
  • Reactive oxygen species (ROS) are implicated in various cellular processes.
  • DNA damage response pathways are crucial for maintaining genomic stability.

Purpose of the Study:

  • To investigate the mitogenic properties of Ras-induced ROS.
  • To explore the link between ROS, DNA damage response, and cellular proliferation.
  • To identify the specific molecular axis responsible for ROS induction.

Main Methods:

  • Studies utilizing cultured cells.
  • In vivo experiments with zebrafish models.
  • Analysis of clinical patient material.

Main Results:

  • Ras-induced ROS exhibit mitogenic properties.
  • A consistent role for the RAS-RAC1-NOX4 axis was observed across different models.
  • This axis is involved in ROS induction, hyperproliferation, and senescence.

Conclusions:

  • The RAS-RAC1-NOX4 axis is a critical mediator of Ras-driven cellular changes.
  • Understanding this pathway offers insights into cancer development and aging.
  • Targeting this axis may have therapeutic implications.
Keywords:
DNA Damage Response (DDR)NADPH oxidase (Nox)oncogene-induced cellular senescencereactive oxygen species (ROS)

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