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SIN3B, the SASP, and pancreatic cancer
David J Cantor1, Gregory David1
1Department of Biochemistry and Molecular Pharmacology and NYU Cancer Institute; New York University School of Medicine ; New York, NY, USA.
Molecular & Cellular Oncology
|June 17, 2016
Abstract:
Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study.

