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To die, or not to die: E2F1 never decides by itself during serum starvation
Daitoku Sakamuro1, Watson P Folk1, Alpana Kumari1
1Department of Biochemistry and Molecular Biology; Medical College of Georgia; Georgia Regents University Cancer Center ; Augusta, GA USA.
Molecular & Cellular Oncology
|June 17, 2016
Abstract:
The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.