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SAT1 and glioblastoma multiforme: Disarming the resistance
Adina Brett-Morris1, Mazen Mislmani1, Scott M Welford1
1Department of Radiation Oncology; School of Medicine; Case Western Reserve University ; 10900 Euclid Avenue; Cleveland, OH USA.
Molecular & Cellular Oncology
|June 17, 2016
Abstract:
Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
