Stabilization of phosphatidylethanolamine hydroperoxides in human plasma

When phosphatidylcholine hydroperoxides (PC-OOH) and phosphatidylethanolamine hydroperoxides (PE-OOH) were incubated in normal saline at 37 degrees C, PE-OOH were decomposed more rapidly than PC-OOH, possibly due to Fe2+-binding ability of their polar head-group. In human plasma, both phospholipid hydroperoxides were stable during incubation. Iron ion-trapping ability of plasma components should be responsible for the hydroperoxide-stabilizing effect.