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Meningococcal B vaccination: real-world experience and future perspectives.
Parvanè Kuhdari1, Armando Stefanati1, Silvia Lupi1
1a Department of Medical Sciences , University of Ferrara , Ferrara , Italy.
Pathogens and Global Health
|June 17, 2016
Summary
Invasive meningococcal disease (IMD) is a severe, vaccine-preventable illness. The new 4-component meningococcal serogroup B (4cMenB) vaccine shows promise in preventing outbreaks and should be widely adopted.
Area of Science:
- Vaccinology
- Infectious Diseases
- Public Health
Background:
- Invasive meningococcal disease (IMD) is a significant health threat, associated with high mortality and long-term disability.
- Existing conjugate vaccines have reduced IMD caused by serogroups A, C, W135, and Y.
- Serogroup B meningococcal (MenB) disease has remained a challenge due to difficulties in vaccine development.
Purpose of the Study:
- To review the development and impact of the 4-component meningococcal serogroup B (4cMenB) vaccine.
- To assess the effectiveness of the 4cMenB vaccine in preventing MenB outbreaks.
- To advocate for the inclusion of the 4cMenB vaccine in routine immunization schedules.
Main Methods:
- Review of scientific literature on MenB vaccines and IMD epidemiology.
- Analysis of data from MenB outbreak management, including vaccination coverage and case incidence.
- Evaluation of vaccine efficacy, safety, and real-world effectiveness data.
Main Results:
- Reverse vaccinology enabled the development of the 4cMenB vaccine, targeting prevalent MenB strains globally.
- The 4cMenB vaccine is recommended in numerous countries, including Europe, North America, Australia, and parts of Latin America.
- Outbreak management in US universities demonstrated rapid high vaccination coverage and no new cases in immunized individuals, indicating high effectiveness.
Conclusions:
- The 4cMenB vaccine represents a significant advancement in preventing MenB disease.
- Real-world data, though limited, supports the vaccine's effectiveness in controlling outbreaks.
- Widespread adoption of the 4cMenB vaccine is crucial to complete immunization against Neisseria meningitidis and reduce the overall burden of IMD.
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