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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles.

E K Lenzi1, A Novatski1, P V Farago2

  • 1Departamento de Física, Universidade Estadual de Ponta Grossa, Ponta Grossa, 84030-900, Brazil.

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|June 17, 2016
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Summary
This summary is machine-generated.

A new model using fractional diffusion and kinetic equations explains drug release, including anomalous diffusion and surface relaxation. This model successfully describes capsaicinoids release from microparticles, suggesting burst release is linked to anomalous diffusion.

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Area of Science:

  • * Mathematical modeling of transport phenomena.
  • * Biophysics and pharmaceutical sciences.

Background:

  • * Drug release kinetics from microparticles often involve complex diffusion and surface interactions.
  • * Traditional diffusion models may not capture anomalous diffusion or non-Debye surface relaxation processes.

Purpose of the Study:

  • * To introduce a generalized model for diffusion coupled with surface kinetics.
  • * To investigate scenarios including anomalous diffusion and non-Debye surface relaxation.
  • * To apply the model to experimental drug release data.

Main Methods:

  • * Development of a general model based on fractional diffusion equations.
  • * Coupling the diffusion equation with a kinetic equation via boundary conditions.
  • * Application and validation of the model using experimental data of capsaicinoids release from Poly (ε-caprolactone) microparticles.

Main Results:

  • * The model successfully describes various diffusion scenarios, including anomalous diffusion and surface relaxation.
  • * The model shows good agreement with experimental data for capsaicinoids release.
  • * A correlation between the initial burst drug release and anomalous diffusion is proposed.

Conclusions:

  • * The proposed fractional diffusion-kinetic model provides a robust framework for analyzing complex drug release systems.
  • * Anomalous diffusion is a potential mechanism underlying the burst release effect observed in Poly (ε-caprolactone) microparticles.
  • * The model's ability to capture non-Debye surface relaxation broadens its applicability to diverse material-drug interactions.