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Involvement of bands 9q21-q22 in five cases of acute nonlymphocytic leukemia
C Sreekantaiah1, M R Baer, H D Preisler
1Cytogenetics Laboratory, Roswell Park Memorial Institute, Buffalo, New York.
Cancer Genetics and Cytogenetics
|May 1, 1989
Abstract:
Five patients with acute nonlymphocytic leukemia (ANLL) with chromosomal aberrations involving bands 9q21-q22 are described. The abnormalities were an interstitial deletion in two cases of ANLL FAB type M4 and M4 with eosinophilia, a terminal deletion in two cases of M4 and M5 type ANLL, and a translocation in an M2 ANLL. A review of reported cases of ANLL with abnormalities of chromosome 9 revealed a clustering of breaks at the region 9q21-q22, suggesting a possible role for these bands in leukemogenesis.