Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

53.3K
Overview
53.3K
Cross-reactivity00:42

Cross-reactivity

33.7K
Overview
33.7K
Vaccines01:21

Vaccines

2
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
2
Immunological Memory01:23

Immunological Memory

17.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.7K
Vaccine Production01:23

Vaccine Production

9
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
9
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.9K
Overview
85.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Jack Fowle: Combining Values, Experience, and Teamwork to Improve Risk Analysis.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same author

Wayne Landis: Evolution of Ecological Risk Assessment.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same author

Effect of neonatal BCG vaccination on oral herpes in early childhood: A nested study within a randomised controlled trial.

Vaccine·2026
Same author

Vanadium salt inhibits osteoclast formation and preserves bone integrity in a rat model of type-1 diabetes associated bone loss.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2026
Same author

Skeletal effect of semaglutide and tirzepatide in patients with increased risk of fractures.

The Journal of clinical endocrinology and metabolism·2026
Same author

Antiphospholipid Syndrome in Orthopaedic Foot and Ankle Surgery: A Propensity-Matched Analysis.

Foot & ankle orthopaedics·2026

Related Experiment Video

Updated: Mar 19, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

9.2K

Heterologous vaccine effects.

Mitra Saadatian-Elahi1, Peter Aaby2, Frank Shann3

  • 1Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon cedex 03, France.

Vaccine
|June 18, 2016
PubMed
Summary

Vaccines can have non-specific effects (NSEs) beyond their intended purpose, influencing the immune system broadly. Further research is needed to understand the mechanisms and extent of these important off-target effects.

Keywords:
Conference reportHeterologous effectNon-antigen-specific effectsOff-target effectsVaccine

More Related Videos

Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
08:13

Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination

Published on: January 20, 2019

22.7K
Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

5.5K

Related Experiment Videos

Last Updated: Mar 19, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

9.2K
Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
08:13

Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination

Published on: January 20, 2019

22.7K
Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

5.5K

Area of Science:

  • Immunology
  • Epidemiology
  • Systems Biology
  • Public Health
  • Regulatory Science

Background:

  • Vaccines can induce non-specific effects (NSEs), also known as off-target effects, impacting immune responses beyond the targeted pathogen.
  • These NSEs are increasingly recognized as a significant biological process by immunologists and epidemiologists.
  • The full extent and underlying mechanisms of vaccine-induced NSEs require further investigation.

Purpose of the Study:

  • To holistically examine the immunological mechanisms and translational implications of vaccine NSEs.
  • To foster interdisciplinary discussion among experts in immunology, systems biology, epidemiology, bioinformatics, public health, and regulatory science.
  • To identify and discuss potential future research pathways for studying vaccine NSEs.

Main Methods:

  • A conference was convened to discuss NSEs of vaccines.
  • Case studies of live attenuated and non-live vaccines were analyzed.
  • Discussions focused on immunological mechanisms and epidemiological observations of NSEs.

Main Results:

  • Examined NSE observations through case studies of various vaccine types.
  • Discussed potential biological mechanisms underlying NSEs.
  • Identified and deliberated on future research directions for vaccine NSEs.

Conclusions:

  • Vaccine NSEs represent an important area of study with implications for public health.
  • An interdisciplinary approach is crucial for understanding the complex mechanisms of NSEs.
  • Further research is warranted to elucidate the extent and pathways of these off-target effects.