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Related Concept Videos

Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
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Liver Histology01:27

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
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Related Experiment Video

Updated: Mar 19, 2026

Multiphoton Microscopic Observation of Vessels in Mouse Liver Tissue
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Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy.

Haolu Wang1, Xiaowen Liang1, Germain Gravot2

  • 1Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia.

Journal of Biophotonics
|June 18, 2016
PubMed
Summary

Multiphoton microscopy (MPM) offers deep tissue imaging for liver studies. Combining MPM with fluorescence lifetime imaging (FLIM) enhances understanding of liver diseases from the cellular level to clinical applications.

Keywords:
Multiphoton microscopydiseasesfluorescence lifetime imagingfunctionlivermorphology

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Area of Science:

  • Hepatology
  • Biomedical Imaging
  • Microscopy

Background:

  • Multiphoton microscopy (MPM) is increasingly utilized in liver research.
  • MPM offers deep tissue penetration with reduced photobleaching and phototoxicity.
  • It aids in understanding liver cellular morphology, microenvironment, and immune responses.

Purpose of the Study:

  • To review the principles, opportunities, applications, and limitations of MPM in hepatology.
  • To highlight the role of fluorescence lifetime imaging (FLIM) in MPM for liver studies.
  • To discuss the potential of MPM-FLIM for advancing liver disease research.

Main Methods:

  • Review of existing literature on multiphoton microscopy in liver studies.
  • Emphasis on fluorescence lifetime imaging (FLIM) techniques.
  • Analysis of applications in both healthy and diseased liver models.

Main Results:

  • MPM provides valuable insights into live liver tissues.
  • FLIM enhances quantification and specificity for endogenous and exogenous molecules.
  • MPM-FLIM enables detailed analysis of cellular and molecular dynamics in the liver.

Conclusions:

  • MPM-FLIM is a powerful tool for studying liver diseases.
  • This technology can advance the understanding of liver disease mechanisms.
  • Future applications may lead to real-time histology for human liver diseases.