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Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface

Elango Bhakkiyalakshmi1, Kesavan Dineshkumar2, Suresh Karthik1

  • 1Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India.

Bioorganic & Medicinal Chemistry
|June 18, 2016
PubMed
Summary

Pterostilbene (PTS) inhibits the Keap1-Nrf2 protein-protein interaction, activating Nrf2. This natural compound shows potential for treating oxidative stress disorders.

Keywords:
AREKeap1Molecular dockingMolecular dynamic simulationNrf2Pterostilbene

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