Related Experiment Video

Updated: Mar 19, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.8K

The LDL/HDL ratio and atherosclerosis in ankylosing spondylitis

A Kucuk1, A Uğur Uslu2, A Icli3

  • 1Division of Rheumatology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey. drademk@yahoo.com.

Zeitschrift Fur Rheumatologie
|June 18, 2016
PubMed

Insights

Ankylosing spondylitis patients show increased atherosclerosis risk markers like carotid intima-media thickness (CIMT), oxidative stress, and ischemic modified albumin. The LDL/HDL ratio is higher but not a reliable predictor of heart disease in AS.

Area of Science:

  • Cardiovascular Research
  • Rheumatology
  • Biochemistry

Background:

  • Ankylosing spondylitis (AS) is linked to cardiovascular complications, including atherosclerosis.
  • Systemic inflammation, oxidative stress, and dyslipidemia are key risk factors for atherosclerosis in AS patients.
  • Carotid intima-media thickness (CIMT) serves as a marker for subclinical atherosclerosis.

Purpose of the Study:

  • To investigate the relationship between CIMT, LDL/HDL ratio, total oxidant status (TOS), and ischemic modified albumin (IMA) in AS patients.
  • To assess the predictive value of the LDL/HDL ratio for atherosclerotic heart disease in AS.
  • To evaluate oxidative stress and ischemic markers in AS patients.

Main Methods:

  • Sixty AS patients and 54 age- and gender-matched controls were enrolled.
  • Measurements included CIMT, LDL/HDL ratio, TOS, and IMA.
  • The Modified New York Criteria were used for AS diagnosis.

Main Results:

  • AS patients exhibited significantly higher IMA, TOS, CIMT, and LDL/HDL ratios compared to controls.
  • A positive correlation was observed between CIMT and the LDL/HDL ratio in AS patients.
  • IMA and TOS were elevated, indicating increased oxidative stress and ischemia.

Conclusions:

  • Elevated CIMT, IMA, and TOS suggest a heightened risk of atherosclerotic heart disease in AS patients.
  • While the LDL/HDL ratio was higher in AS patients, its correlation with CIMT was weak.
  • The LDL/HDL ratio is not a dependable marker for predicting atherosclerotic heart disease in AS patients.
Abstract

Keywords:
Ankylosing spondylitisAtherosclerosisDyslipidemiasIschemia-modified albuminOxidative Stress

More Related Videos

Quantification of Atherosclerosis in Mice06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.9K
Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model07:49

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

2.9K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
569
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.9K
Inflammation01:38

Inflammation

Overview
63.9K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.8K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
717
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.5K