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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
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Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Improving Cure Rates in Onychomycosis.

Aditya K Gupta1,2, Maria Cernea2, Kelly A Foley2

  • 1Department of Medicine, University of Toronto, Toronto, ON, Canada agupta@execulink.com.

Journal of Cutaneous Medicine and Surgery
|June 18, 2016
PubMed
Summary

Improving fungal nail infection (onychomycosis) cure rates requires correct diagnosis, personalized treatment plans, maximized antifungal efficacy, and recurrence prevention strategies for better long-term disease management.

Keywords:
antifungal medicationcomplete curedermatophytesmycological curerecurrencetinea unguium

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Area of Science:

  • Dermatology
  • Mycology

Background:

  • Onychomycosis is a common and persistent fungal nail infection.
  • Treatment failure affects 20-25% of patients, with 10-53% experiencing recurrence.
  • Successful treatment is crucial for long-term management of this condition.

Purpose of the Study:

  • To identify strategies for enhancing cure rates in onychomycosis treatment.
  • To address the challenges of persistent fungal nail infections.

Main Methods:

  • A comprehensive literature review was conducted.
  • The review focused on onychomycosis treatment and recurrence patterns.
  • Treatment approaches and recurrence prevention strategies were summarized.

Main Results:

  • Accurate diagnosis is fundamental for effective onychomycosis treatment.
  • Individualized treatment regimens are essential for patient success.
  • Maximizing antifungal efficacy and preventing recurrence are key components.

Conclusions:

  • Implementing a multi-faceted approach improves onychomycosis treatment outcomes.
  • Correct diagnosis, tailored therapy, optimized antifungal use, and recurrence prevention are vital.
  • These measures contribute to long-term disease control and patient well-being.