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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem.

Karim M Fawzy El-Sayed1, Christof E Dörfer2

  • 1Clinic of Conservative Dentistry and Periodontology, Christian Albrechts University of Kiel, Arnold Heller Straße 3, Haus 26, 24105 Kiel, Germany; Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Egypt.

Stem Cells International
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

Gingival mesenchymal stem/progenitor cells (G-MSCs) offer promising regenerative and immunomodulatory potential for tissue repair. These abundant, easily accessible cells show great promise for future therapeutic applications beyond conventional treatments.

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Periodontal Research

Background:

  • Human gingiva exhibits remarkable scarless wound healing.
  • Gingival mesenchymal stem/progenitor cells (G-MSCs) are abundant and accessible from the gingival lamina propria.
  • G-MSCs possess significant regenerative and immunomodulatory properties.

Purpose of the Study:

  • To review current evidence on G-MSCs.
  • To explore their isolation, characterization, and subpopulations.
  • To summarize their regenerative and immunomodulatory potential and therapeutic applications.

Main Methods:

  • Literature review of scientific evidence on G-MSCs.
  • Analysis of G-MSC isolation, characterization, and subpopulation studies.
  • Examination of G-MSC delivery methods, preconditioning, and in vivo therapeutic applications.

Main Results:

  • G-MSCs are readily obtainable via minimally invasive techniques.
  • Review covers G-MSC isolation, characterization, iPSC-like G-MSCs, and delivery.
  • Experimental therapeutic applications in animal models show promising results.

Conclusions:

  • G-MSCs demonstrate significant tissue reparative/regenerative potential.
  • G-MSCs possess noteworthy immunomodulatory properties.
  • Therapeutic applications of G-MSCs are promising for future biologically based treatments.