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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
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Platelet-Rich Fibrins as Local Drug-Delivery Carriers.

Karim M Fawzy El-Sayed1,2,3, Christof E Dörfer2

  • 1Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

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Summary

Autologous platelet concentrates (APCs) show promise as drug delivery systems, particularly platelet-rich fibrin (PRF) over platelet-rich plasma (PRP). Standardized protocols are needed for effective localized therapies.

Keywords:
antibioticsantifungaldrugplasmaplateletsplatelets‐rich fibrin

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Autologous platelet concentrates (APCs) are being investigated as sustained release vehicles for localized drug delivery.
  • Platelet-rich fibrin (PRF) offers advantages over platelet-rich plasma (PRP) due to its stable fibrin scaffold, enabling better retention of bioactive agents.
  • Current limitations include a lack of standardized preparation protocols for drug-loaded APCs, affecting structural integrity and release kinetics.

Purpose of the Study:

  • To review emerging evidence on APCs as drug delivery vehicles.
  • To compare the efficacy of PRF-based versus PRP-based drug delivery systems.
  • To identify optimal loading strategies and knowledge gaps in current research.

Main Methods:

  • Literature review of studies on autologous platelet concentrates (APCs) for drug delivery.
  • Analysis of evidence for various incorporated bioactive agents (antibiotics, antifungals, etc.).
  • Evaluation of preparation techniques, release profiles, and therapeutic outcomes.

Main Results:

  • PRF demonstrates superior drug retention and sustained release compared to PRP.
  • Incorporation of drugs like antibiotics and antifungals into APCs enhances therapeutic efficacy.
  • Evidence supports APCs for wound healing, regeneration, and targeted antimicrobial/antifungal effects.

Conclusions:

  • Bioactive drug-loaded APCs, especially PRF-based, represent a promising platform for localized therapies.
  • Standardization of preparation protocols and further clinical validation are crucial for widespread adoption.
  • These systems could bridge infection management with precision-guided tissue healing, potentially reducing systemic treatment needs.