Visible-Light-Induced Arylthiofluoroalkylations of Unactivated Heteroaromatics and Alkenes
Yeojin Choi1, Chunghyeon Yu2, Jun Soo Kim3
1Department of Chemistry, Chung-Ang University , 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
Abstract:
Visible-light-induced arylthiofluoroalkylations of unactivated heteroaromatics and alkenes have been developed utilizing readily available arylthiofluoroalkyl sources. This method enables simultaneous installation of sulfur and fluoroalkyl moieties, two important functional groups, which demonstrates its potential use for late-stage modifications in the synthesis of functional molecules. This method can be easily utilized to fine-tune the properties of lead molecules in drug development by controlling the number of fluorine atoms in the reagents.
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