Related Experiment Video
Updated: Mar 19, 2026
06:43
Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
Published on: March 29, 2017
10.5K
Neuropeptide substance P and the immune response
Alireza Mashaghi1, Anna Marmalidou1, Mohsen Tehrani1
1Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114.
Cellular and Molecular Life Sciences : CMLS
|June 18, 2016
Summary
Substance P, a peptide from neurons, plays a key role in cell communication, inflammation, and immunity. Understanding its functions offers insights into modulating immune responses and potential clinical applications.
Area of Science:
- Neuroimmunology
- Molecular Biology
- Cellular Signaling
Background:
- Substance P is a peptide neurotransmitter involved in nociception and inflammation.
- It facilitates paracrine and endocrine signaling, mediating neuron-immune cell communication.
- Immune cells also secrete Substance P, highlighting its integral role in immune responses.
Purpose of the Study:
- To review current knowledge on Substance P and its receptors.
- To summarize its physiological and pathological roles.
- To focus on recent developments in Substance P immunobiology and clinical implications.
Main Methods:
- Literature review of existing studies on Substance P.
- Analysis of animal models to understand peptide functions.
- Synthesis of data on Substance P's role in cell communication and immune modulation.
Main Results:
- Substance P modulates immune cell proliferation and cytokine production.
- It plays functional roles in immune cell mobilization and activity.
- Evidence supports Substance P's importance in neuron-immune cell interactions.
Conclusions:
- Substance P is a critical mediator in neuro-immune crosstalk.
- Its modulation of immune responses has significant clinical implications.
- Further research into Substance P's immunobiology is warranted for therapeutic development.
Related Concept Videos
01:29Immune Response Against Viral Pathogens
2.4K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.4K
01:25Immune Surveillance by NK Cells and Phagocytes
9.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.4K
01:44Nociception
34.2K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
34.2K
01:28Inflammatory Response
18.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
18.2K
01:30Regulation of Food Intake
3.1K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.1K
01:27Cytotoxic T Cells-mediated Immune Response
7.8K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.8K