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Alien Hand Syndrome.

Anhar Hassan1, Keith A Josephs2

  • 1Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. hassan.anhar@mayo.edu.

Current Neurology and Neuroscience Reports
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

Alien hand syndrome (AHS) is a rare neurological disorder causing involuntary limb movements and a loss of limb ownership. This review updates understanding of AHS classification, causes, and treatments.

Keywords:
Alien limbCallosalCorticobasal syndromeFrontalParietalStroke

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Area of Science:

  • Neurology
  • Neuroscience
  • Movement Disorders

Background:

  • Alien hand syndrome (AHS) is a rare neurological disorder characterized by involuntary limb movements and a diminished sense of limb ownership.
  • It typically affects the hand but can also involve the leg.
  • Previously attributed to stroke or surgery, neurodegenerative conditions are now recognized as common causes.

Purpose of the Study:

  • To review and update current understanding of alien hand syndrome.
  • To cover advances in classification, pathophysiology, etiology, and treatment.

Main Methods:

  • Literature review of structural and functional imaging studies.
  • Analysis of clinical studies and proposed pathophysiological theories.

Main Results:

  • Identified anterior (frontal, callosal) and posterior variants of AHS with distinct clinical features and lesions.
  • Implicated the supplementary motor area, pre-supplementary motor area, and their network connections in the frontal variant.
  • Linked the inferior parietal lobule and its connections to the posterior variant.

Conclusions:

  • AHS pathophysiology involves specific frontal and parietal brain networks.
  • Understanding the etiology, including neurodegenerative causes, is crucial for diagnosis and management.
  • Further research is needed to refine treatment strategies for AHS.