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Updated: Aug 14, 2025

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Deep Brain Stimulator Device Infection: The Mayo Clinic Rochester Experience.

Hussam Tabaja1, Jason Yuen2, Don Bambino Geno Tai1

  • 1Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Open Forum Infectious Diseases
|January 12, 2023
PubMed
Summary
This summary is machine-generated.

Deep brain stimulator infections are more common in primary implantations than revisions. Complete device removal is best for deep infections, though device salvage is a viable option in some cases.

Keywords:
DBS-related infectiondeep brain stimulatordevice-related infectionneuromodulationneurosurgery infection

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Area of Science:

  • Neurosurgery
  • Infectious Diseases
  • Medical Device Technology

Background:

  • Deep brain stimulator (DBS) infections are a known complication impacting therapy.
  • This study details the experience with DBS-related infections at Mayo Clinic Rochester.

Purpose of the Study:

  • To analyze the incidence, risk factors, pathogens, and management outcomes of DBS-related infections.
  • To compare infection rates between primary implantations and revision surgeries.

Main Methods:

  • Retrospective study of adult patients (≥18 years) undergoing DBS procedures from 2000-2020.
  • Analysis of 1896 procedures in 1087 patients, examining infection rates, timing, risk factors, and treatment approaches.

Main Results:

  • Infection occurred in 5% of primary implantations and 2% of revision surgeries.
  • Higher infection risk was associated with longer operative time, higher BMI, male sex, and diabetes.
  • Staphylococcus aureus, coagulase-negative staphylococci, and Cutibacterium acnes were common pathogens; complete device explantation showed fewer treatment failures.

Conclusions:

  • Primary DBS implantations have a higher infection rate than revision surgeries.
  • Complete device explantation is preferred for deep infections.
  • Device salvage is a reasonable approach in select cases with a low complication rate.