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FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression
Lyubov Bryushkova1, Clement Zai2, Sheng Chen3
1Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Psychiatry Research
|June 18, 2016
Abstract:
Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.