Linkage analysis with cohort effects: an application to X-linkage
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1Department of Psychiatry, Washington University, St. Louis, MO.
Genetic Epidemiology
|January 1, 1989
Abstract:
The LIPED program has been modified to incorporate cohort effects in a linkage analysis. Very significant positive lod scores are obtained between bipolar affective disorder and both the deutan and protan markers on the X-chromosome. Lod score methods are shown to be sensitive to the specification of the age of onset distributions and the parameters of the model of transmission.