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Updated: Aug 18, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Linkage analysis with inbreeding
1Department of Psychiatry, Washington University, St. Louis, MO.
Abstract:
For computational reasons, linkage analysis of highly inbred pedigrees is often performed under the assumption that spouse pairs are genetically unrelated. A formulation of the likelihood of a pedigree which takes into account all of the genealogical information omega, for an arbitrary relationship between a pair of spouses, is proposed. Lod scores at a recombination fraction of 0 for an inbred three-member nuclear family are presented.
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