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Updated: Mar 19, 2026

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
Published on: April 19, 2021
Elimination of the baseline distortions in WURST-CPMG static experiments
Bo Peng1, Ming Shen1, Jean-Paul Amoureux2
1School of Physics and Materials Science & Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China.
Abstract:
The WURST-CPMG pulse sequence enables: (i) observing very broad spectra due to WURST excitation, and (ii) increasing the S/N ratio due to CPMG acquisition. However, strong baseline distortions may be observed, which make the extraction of the tensor information difficult. We propose a slight modification of the sequence, WURST-CPMGM, in which we skip the first M echoes and we only acquire the following ones. This simple treatment mostly eliminates the strong background signal and the ring down effects, leading to a flat baseline.
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