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Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
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Published on: July 13, 2014

Evaluation of the developmental toxicity of succinate tartrates in rats

D W Petersen1, G P Daston, J L Schardein

  • 1Procter and Gamble Company, Ivorydale Technical Center, Cincinnati, OH.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|April 1, 1989
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...