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Updated: Mar 19, 2026
Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Postnatal corticosteroids and risk of retinopathy of prematurity
Tammy Z Movsas1, Alan R Spitzer2, Ira H Gewolb3
1Zietchick Research Institute, Plymouth, Michigan and Midland County Department of Public Health, Midland, Michigan.
Purpose:
To investigate the association between postnatal steroids and retinopathy of prematurity (ROP) in neonates born with birth weights at the limit of viability (<500 g).
Methods:
Data from the Pediatrix BabySteps Clinical Warehouse were retrospectively reviewed. The study population consisted of 1,472 neonates with birth weights of <500 g who were discharged alive from 167 NICUs between 1996 and 2013. Statistical significance for unadjusted comparisons between groups was determined using the χ(2) or t test. Logistic regression was used to calculate odds of ROP.
Results:
In multivariate analysis, the odds of any ROP for steroid treated infants was 1.6 (95% CI, 1.2-2.2) compared to nontreated infants; the odds of advanced ROP was 1.7 (95% CI, 1.3-2.3).
Conclusions:
In our large study cohort of critically low birth weight infants ROP was more common in neonates exposed to postnatal steroids.
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