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Updated: Mar 19, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
Published on: August 12, 2014
Harnessing gene and drug delivery for vascularizing engineered tissue platforms
Gabrielle C Lam1, Michael V Sefton2
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Abstract:
Enhancement of tissue vascularization is a therapeutic target for many ischemic conditions, and is crucial for successful engraftment of therapeutic cells for tissue regeneration. The authors present opportunities for using these platforms for dissecting the role of angiogenic mechanisms and highlight recent gene and drug delivery strategies for enhancing vascularization of engineered tissues. Modular tissue engineering is featured as an example.

