Related Experiment Video
Updated: Mar 19, 2026
06:28
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
1.5K
Acute exercise amplifies inflammation in obese patients with COPD
F Rodrigues1, A L Papoila2, D Ligeiro3
1Serviço Pneumologia, Hospital Pulido Valente, Centro Hospitalar Lisboa Norte, Portugal; Faculdade de Medicina, Universidade de Lisboa, Portugal.
Revista Portuguesa De Pneumologia
|June 21, 2016
Summary
Systemic inflammation in chronic obstructive pulmonary disease (COPD) is linked to body mass index (BMI) extremes, not exercise. Both underweight and obese COPD patients show altered inflammatory gene expression at rest and post-exercise.
Area of Science:
- Pulmonary Medicine and Immunology
- Molecular Biology and Genetics
Background:
- Systemic inflammation is a proposed factor in chronic obstructive pulmonary disease (COPD) pathogenesis and its systemic effects.
- Previous research on systemic inflammation in COPD patients, particularly concerning exercise and exacerbations, has yielded conflicting results.
- Understanding the relationship between exercise, systemic inflammation, and patient variables is crucial for managing COPD.
Purpose of the Study:
- To evaluate inflammatory gene expression at rest and at 1 and 24 hours after strenuous exercise in COPD patients.
- To identify patient variables, specifically body mass index (BMI), associated with inflammatory gene expression.
- To investigate the impact of short-term exercise on systemic inflammatory markers in COPD.
Main Methods:
- A cross-sectional study involving 21 COPD patients entering a pulmonary rehabilitation program.
- Collection of demographic, clinical, and functional data, including BMI and GOLD grade.
- Analysis of inflammatory gene expression (IFNg, IL1b, IL6, IL8, TNFa, TGFb1, iNOS) via reverse transcriptase polymerase chain reaction (RT-PCR) at rest and post-exercise.
Main Results:
- No statistically significant difference in inflammatory gene expression was observed at rest compared to 1 and 24 hours after maximal exercise.
- A significant association was found between BMI and inflammatory gene expression at all time points.
- Inverse association with low BMI and positive association with obesity were noted for several inflammatory genes (IL1b, IL6, TNFa, TGFb1, iNOS).
Conclusions:
- Short-term strenuous exercise does not appear to enhance systemic inflammatory gene expression in COPD patients.
- Both underweight and obese COPD patients exhibit altered inflammatory gene expression, suggesting BMI extremes as potential links to systemic inflammation.
- Further large-scale studies are needed to confirm these findings and exclude confounding factors like obstructive sleep apnea (OSA) or obesity hypoventilation syndrome (OHS) in obese patients.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:24Chronic Obstructive Pulmonary Disease
3.0K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.0K
01:20Exercise and Cardiovascular Response
4.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.9K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.1K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
4.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.0K
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.1K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.1K