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The Current and Evolving Role of PET in Personalized Management of Lung Cancer

Esther Mena1, Anusha Yanamadala1, Gang Cheng2

  • 1Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA.

PET Clinics
|June 21, 2016
PubMed

Insights

Genomic profiling transformed lung cancer treatment, guiding targeted therapies for mutations like EGFR and ALK. This review explores these genomic advances and their impact on positron emission tomography (PET) imaging for lung cancer.

Area of Science:

  • Oncology
  • Genetics
  • Radiology

Background:

  • Personalized treatment of lung cancer is increasingly driven by tumor genomic profiling.
  • Key discoveries include epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) fusions, and Kristen-Rat-Sarcoma (KRAS)/MET protooncogene alterations.
  • Positron emission tomography (PET) imaging is vital for assessing lung cancer biology and treatment response.

Purpose of the Study:

  • To review significant genomic discoveries in lung cancer.
  • To discuss the implications of these genomic findings for functional PET imaging.

Main Methods:

  • Literature review of genomic discoveries in lung cancer.
  • Analysis of the role of PET imaging in relation to these genomic alterations.

Main Results:

  • Genomic profiling has identified actionable targets, revolutionizing non-small cell lung cancer (NSCLC) treatment.
  • Targeted therapies (e.g., tyrosine kinase inhibitors) have emerged based on these discoveries.
  • PET imaging can reflect the biological behavior influenced by these genomic changes.

Conclusions:

  • Genomic discoveries are fundamentally changing lung cancer management.
  • Integrating genomic information with PET imaging offers new avenues for personalized therapy assessment and monitoring in lung cancer.
Keywords:
GenomicsLung cancerManagementPET/CT imagingPersonalized medicine

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