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Related Experiment Video

Updated: Mar 19, 2026

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

8.4K

3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs.

Stephanie Knowlton1, Chu Hsiang Yu, Fulya Ersoy

  • 1Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA.

Biofabrication
|June 21, 2016
PubMed
Summary
This summary is machine-generated.

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Three-dimensional (3D) printing enables low-cost, rapid fabrication of microfluidic chips. This technology enhances 3D cell culture and creates complex channels for bioengineering applications.

Area of Science:

  • Bioengineering
  • Materials Science
  • Microfluidics

Background:

  • Traditional microfluidic chip fabrication is expensive and labor-intensive.
  • 3D printing offers a cost-effective and rapid prototyping alternative.
  • Efficient design iterations are crucial for microfluidic device development.

Purpose of the Study:

  • To demonstrate a low-cost, single-step fabrication of 3D transparent microfluidic chips.
  • To enhance 3D-printed microfluidic devices with 3D cell encapsulation and patterning.
  • To explore the use of these devices as controllable 3D cell culture environments.

Main Methods:

  • Stereolithography-based desktop 3D printing for single-step fabrication.
  • Industrial polyjet technology for two-step fabrication.

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Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
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Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

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Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
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Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks

Published on: December 21, 2019

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Related Experiment Videos

Last Updated: Mar 19, 2026

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

8.4K
Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
10:55

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

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Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
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Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks

Published on: December 21, 2019

20.1K
  • Incorporation of photocrosslinkable gelatin methacryloyl (GelMA) for cell encapsulation and patterning.

    • Main Results:

    • Successful fabrication of functional 3D microfluidic chips using both 3D printing techniques.
    • Demonstrated capability for 3D cell encapsulation and spatial patterning within GelMA.
    • Creation of complex 3D microfluidic channels enabling predictable fluid flow control.
    • Validation of the platform as a long-term 3D cell culture environment.

    Conclusions:

    • 3D printing provides a rapid, low-cost method for fabricating advanced microfluidic devices.
    • The developed platform supports sophisticated 3D cell culture and spatial patterning.
    • This technology advances the engineering of physiological systems for bioengineering.