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A Bock1, R Geske2, B Schnackenburg3
1Abteilung Neuroradiologie, Klinik für Radiologie und Neuroradiologie (Chefarzt: Priv.-Doz. Dr. H. Lange), Klinikum Neubrandenburg, Germany.
Klinische Neuroradiologie
|June 21, 2016
Summary
Cerebrospinal fluid (CSF) flow via the cerebral aqueduct can now be quantified using MRI. The interthalamic width of the third ventricle serves as a reference to define normal CSF stroke volume per cardiac cycle (SVcc).
Area of Science:
- Neuroimaging
- Fluid dynamics
- Neurology
Context:
- Cerebrospinal fluid (CSF) flow quantification via the cerebral aqueduct using 2D-phase-contrast MRI is valuable but lacks normative data.
- Stroke volume of CSF per cardiac cycle (SVcc) is a key metric for assessing flow volume.
- Establishing normative values for SVcc is crucial for clinical application of this non-invasive MRI technique.
Purpose:
- To evaluate the interthalamic width of the third ventricle as a reference system for SVcc.
- To define normal CSF flow through the cerebral aqueduct using MRI measurements.
- To correlate SVcc with interthalamic width in a healthy patient cohort.
Summary:
- A strong correlation (r=0.822) was found between SVcc and interthalamic width in 83 healthy patients.
- Abnormal SVcc values were observed in patients with specific neurological conditions and heart rate variations.
- A linear regression model (y = 22.2*x + 43.5) was established for all 107 patients to assess SVcc relative to interthalamic width.
Impact:
- This study provides a method to differentiate between hyperdynamic, hypodynamic, and normodynamic CSF flow through the cerebral aqueduct.
- The findings enable the definition of normal CSF flow parameters, enhancing clinical utility.
- Future evaluations should incorporate additional imaging findings and heart rate for comprehensive assessment.
