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Broad-band excitation in indirectly detected (14)N overtone spectroscopy with composite pulses
Ming Shen1, Qun Chen1, Jean-Paul Amoureux1
1Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.
Abstract:
We show here that composite pulses allow broad-band excitation of nitrogen-14 overtone frequencies in proton detected D-HMQC experiments (referred to (1)H-{NOTDQ14} D-HMQC). Experimental verifications have been performed on glycine, L-histidine and N-acetyl-valine (NAV) samples. Composite pulses enable symmetric excitations of (14)N sites with large shift differences. Therefore, this approach is promising for recording high resolution (1)H-{NOTDQ14} D-HMQC spectra of most amino-acids, pharmaceutical samples and peptides.
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