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Shape-Changing Photodegradable Hydrogels for Dynamic 3D Cell Culture.

Elli Käpylä1, Stephanie M Delgado1, Andrea M Kasko1,2

  • 1Department of Bioengineering, University of California Los Angeles , 410 Westwood Plaza, 5121 Engineering V, Los Angeles, California 90095, United States.

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Summary

Researchers developed self-folding photodegradable hydrogels that transform from 2D sheets to 3D tubes using UV light. These scaffolds support cell culture, enabling controlled 2D-3D shape changes with viable cells for tissue engineering applications.

Keywords:
3D cell cultureC2C12bio-origamihydrogelphotodegradableself-foldingshape change

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Photochemistry

Background:

  • Self-folding materials inspired by nature offer dynamic shape-changing capabilities.
  • Hydrogels are versatile biomaterials for cell culture and tissue engineering.
  • Photodegradable polymers enable light-controlled material transformations.

Purpose of the Study:

  • To develop self-folding, photodegradable hydrogel scaffolds for cell culture.
  • To investigate light-induced 2D-to-3D shape transformation in hydrogels with cells.
  • To demonstrate controlled folding and cell viability within engineered tubular structures.

Main Methods:

  • Fabrication of poly(ethylene glycol) diacrylate hydrogel thin films with ortho-nitrobenzyl (o-NB) moieties.
  • UV light exposure to create cross-link density gradients, inducing differential swelling and folding.
  • Functionalization with RGD peptide for cell adhesion.
  • Seeding and encapsulation of C2C12 mouse myoblasts before or after folding.
  • Assessment of cell viability and adhesion within folded structures.

Main Results:

  • UV light exposure induced controlled folding of hydrogels into tubular structures.
  • Folding and relaxation of tubular structures were tunable by UV dose and polymer composition.
  • C2C12 myoblasts adhered to and survived within the folded hydrogel tubes.
  • Folded structures achieved diameters as small as 1 mm, mimicking muscle fascicles.
  • Cell viability was maintained after UV-induced folding.

Conclusions:

  • Photodegradable hydrogels can be engineered into self-folding scaffolds for 2D-3D shape changes.
  • This system supports seeded and encapsulated cells, maintaining their viability.
  • The technology enables user-directed, light-triggered cell-laden construct formation for potential tissue engineering applications.