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Related Concept Videos

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

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The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Oral Drug Delivery Systems: Introduction01:23

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Drug Dosage Regimen: Overview01:15

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Two-Compartment Open Model: IV Bolus Administration01:18

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The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
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Extraction of Plant-based Capsules for Microencapsulation Applications
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BASICS OF COMPOUNDING: Capsules.

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    Summary
    This summary is machine-generated.

    Capsules offer flexible dosing options for medications, unlike standard tablets. This review covers capsule types, preparation, quality control, and patient counseling for optimal drug delivery.

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    Area of Science:

    • Pharmaceutical Sciences
    • Drug Delivery Systems

    Background:

    • Capsules have been a cornerstone of medication administration for over a century.
    • Unlike tablets, capsules allow for extemporaneous preparation, offering significant dosing flexibility.

    Purpose of the Study:

    • To provide a comprehensive overview of pharmaceutical capsules.
    • To discuss various aspects of capsule formulation, preparation, and application in drug delivery.

    Main Methods:

    • Literature review of capsule definitions, types, and applications.
    • Discussion of capsule composition, preparation techniques, and the encapsulation process.
    • Exploration of quality control, packaging, storage, stability, and patient counseling.

    Main Results:

    • Capsules provide a versatile dosage form with customizable strengths and formulations.
    • Key considerations include physiochemical properties, quality control, and appropriate packaging for stability.
    • Patient counseling is crucial for selecting the correct capsule size and ensuring proper use.

    Conclusions:

    • Extemporaneous compounding of capsules enhances therapeutic flexibility for healthcare providers.
    • A thorough understanding of capsule characteristics is vital for effective drug delivery.
    • This article serves as a guide to capsule technology, from preparation to patient administration.