Related Experiment Video
Updated: Mar 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
EPIDERMOLYSIS BULLOSA IN THE NEWBORN
We present the case of a new-born baby girl who was delivered at term to a young primigravida mother. The pregnancy was booked late and had no antenatal medical or surgical complications. The baby was born vaginally and had a normal initial examination. However after three hours of birth the baby started to develop skin blisters after minor trauma/friction. The baby was seen by a Dermatologist who diagnosed the condition to be Epidermolysis Bullosa. This hereditary condition is extremely rare, and even rarer is such an early presentation in a neonate. It is caused by mutations in the genes coding for the structural proteins of the skin and is characterized by development of vesicles and blisters. The mainstay of management is supportive care. The baby was discharged on request of the parents on second day of life without any complications.
We present the case of a new-born baby girl who was delivered at term to a young primigravida mother. The pregnancy was booked late and had no antenatal medical or surgical complications. The baby was born vaginally and had a normal initial examination. However after three hours of birth the baby started to develop skin blisters after minor trauma/friction. The baby was seen by a Dermatologist who diagnosed the condition to be Epidermolysis Bullosa. This hereditary condition is extremely rare, and even rarer is such an early presentation in a neonate. It is caused by mutations in the genes coding for the structural proteins of the skin and is characterized by development of vesicles and blisters. The mainstay of management is supportive care. The baby was discharged on request of the parents on second day of life without any complications.
Related Concept Videos
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Clinical Applications of Epidermal Stem Cells
Renewal of Skin Epidermal Stem Cells
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...

